Article

C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation

2025-11-29

Abstract excerpt

NLRP10 is an atypical member of the NOD-like receptor (NLR) family because it lacks a leucine-rich repeat domain at its C-terminus. Recently, NLRP10 has been shown to form an inflammasome, however, the mechanism and the trigger of activation remain elusive. Here, we show that in human epithelial cells and keratinocytes NLRP10 oligomerises in response to the stressor m -3M3FBS. NLRP10 co-localises with ASC upon ov...

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Literature Corpus work: e17a6ef1-ff2e-585c-8ab5-5f71b57eceaf
DOI: 10.1101/2025.11.27.690698

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