Article

Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation

2021-09-16

Abstract excerpt

<h4>Summary</h4> Inflammasome complexes are pivotal in the innate immune response to pathogens and other danger signals 1–4 . The NLRP3 inflammasome is activated in response to a broad variety of cellular stressors. Most of the stimuli act in a potassium efflux-dependent manner but a primary and converging sensing mechanism by the NLRP3 receptor initiating inflammasome assembly remains ill-defined. Here we show...

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Literature Corpus work: 319999c8-455e-5e02-ac14-cf32dedb93ae
DOI: 10.1101/2021.09.14.460331

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