Article

<i>In vivo</i> cellular localisation and nanoscale organisation of NLRP3 inflammasomes

2026-08-12

Abstract excerpt

The NLRP3 inflammasome is a critical regulator of inflammation, yet the localisation, organisation, and cellular sources of endogenous NLRP3 inflammasomes remain incompletely understood. Here, we generated NLRP3-mScarlet-I endogenous reporter mice enabling visualisation of NLRP3 at physiological levels in primary cells and in vivo . We show that activated NLRP3 associated with PI4P-positive membranes from multipl...

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Literature Corpus work: 058e484b-d335-53f9-860e-8caaed423df8
DOI: 10.64898/2026.08.06.743215

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