Article
NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
Redox biology - 1 Jan 2015
Abderrazak Amna, Syrovets Tatiana, Couchie Dominique, El Hadri Khadija, Friguet Bertrand, Simmet Thomas, Rouis Mustapha
Abstract excerpt
IL-1β production is critically regulated by cytosolic molecular complexes, termed inflammasomes. Different inflammasome complexes have been described to date. While all inflammasomes recognize certain pathogens, it is the distinctive feature of NLRP3 inflammasome to be activated by many and diverse stimuli making NLRP3 the most versatile, and importantly also the most clinically implicated inflammasome. However,...
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