Article

A detailed Molecular Network Map and Model of the NLRP3 Inflammasome

2023-06-01

Abstract excerpt

The NLRP3 inflammasome is a key regulator of inflammation that responds to a broad range of stimuli. The exact mechanism of activation has not been determined, but there is a consensus on cellular potassium efflux as a major common denominator. Once NLRP3 is activated, it forms high-order complexes together with NEK7 that trigger aggregation of ASC into specks. Typically, there is only one speck per cell, consiste...

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Literature Corpus work: d2b29ffc-e637-560a-b0b8-61dee28868fc
DOI: 10.1101/2023.05.31.543045

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