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Article

Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation

1 Jan 2025

Abstract excerpt

The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays a critical role in the innate immune response to both infections and sterile stressors. Dysregulated NLRP3 activation has been implicated in a variety of autoimmune and inflammatory diseases, including cryopyrin-associated periodic fever syndromes, diabetes,...

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PMID: 39816134
DOI: 10.1097/in9.0000000000000053

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