Article
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.
Nature communications - 17 Nov 2021
Wu Kelvin Ka Lok, Long KeKao, Lin Huige, Siu Parco Ming Fai, Hoo Ruby Lai Chong, Ye Dewei, Xu Aimin, Cheng Kenneth King Yip
Abstract excerpt
Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion of the endosomal adaptor protein APPL1 impairs mitophagy, leading to accumulation of damaged mitochondria producing reactive oxygen species (ROS) and oxidized...
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