Article

NLRP3 acts as a direct sensor of intracellular potassium ions

2026-03-12

Abstract excerpt

<h4>Summary</h4> The NLRP3 inflammasome is a sentinel of cellular homeostasis, and its activation triggers the assembly of a molecular machinery that drives inflammation in infection, cardiovascular, metabolic, and neurodegenerative diseases. The majority of the many triggers known to activate NLRP3 are believed to induce potassium ion (K + ) efflux from the cell as a fundamental danger signal for compromised ce...

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Literature Corpus work: 575491ca-22d8-566f-a894-ed11aa4a54b1
DOI: 10.64898/2026.03.12.707678

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