Article

Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation

2021-09-22

Abstract excerpt

<title>Abstract</title> <p>Inflammasome complexes are pivotal in the innate immune response to pathogens and other danger signals. The NLRP3 inflammasome is activated in response to a broad variety of cellular stressors. Most of the stimuli act in a potassium efflux-dependent manner but a primary and converging sensing mechanism by the NLRP3 receptor initiating inflammasome assembly remains ill-defined. Here we s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2750a7b2-d223-591d-b9e7-c7487b46d030
DOI: 10.21203/rs.3.rs-904605/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activationDOI 10.21203/rs.3.rs-904605/v1Read

Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activationSemantic proximity Read

Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonistsSemantic proximity Read

Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activationSemantic proximity Read

A detailed Molecular Network Map and Model of the NLRP3 InflammasomeSemantic proximity Read

The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.Semantic proximity Read

<i>In vivo</i> cellular localisation and nanoscale organisation of NLRP3 inflammasomesSemantic proximity Read

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.Semantic proximity Read

Influenza A Virus Infection Activates NLRP3 Inflammasome through Trans-Golgi Network Dispersion.Semantic proximity Read

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activationSemantic proximity Read

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathwaysSemantic proximity Read

The Endosomal Recycling Pathway—At the Crossroads of the CellSemantic proximity Read

Release of acidic store calcium is required for effective priming of the NLRP3 inflammasomeSemantic proximity Read