Article

Single cell multiomic analysis of T cell exhaustion <i>in vitro</i>

2019-11-17

Abstract excerpt

A key step in the clinical production of CAR-T cells is the expansion of engineered T cells. To generate enough cells for a therapeutic product, cells must be chronically stimulated, which raises the risk of inducing T-cell exhaustion and reducing therapeutic efficacy. As protocols for T-cell expansion are being developed to optimize CAR T cell yield, function and persistence, fundamental questions about the impac...

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Literature Corpus work: 5bcea506-c312-5851-b579-121c915e5d88
DOI: 10.1101/846048

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