Back to search

Article

Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8 <sup>+</sup> T cells

2021-09-11

Abstract excerpt

T-cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective immunity in chronic viral infections and cancer. Limited knowledge exists of the initial viral and immune dynamics that characterise exhaustion in humans. We studied longitudinal blood samples from a unique cohort of subjects with primary infection using single cell multi-omics to identify the functions and phenotypes of HCV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dce1d808-ee47-572e-be69-4261e9a5ae14
DOI
10.1101/2021.09.09.459584
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8 <sup>+</sup> T cellsDOI 10.1101/2021.09.09.459584
Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infectionSemantic proximity
Single-Cell RNA Sequencing Shows T-Cell Exhaustion Landscape in the Peripheral Blood of Patients with Hepatitis B Virus-Associated Acute-on-Chronic Liver FailureSemantic proximity
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection.Semantic proximity
Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infectionSemantic proximity
Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA SequencingSemantic proximity
An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell TranscriptomicsSemantic proximity
Single cell multiomic analysis of T cell exhaustion <i>in vitro</i>Semantic proximity
Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection.Semantic proximity
Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progressionSemantic proximity
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversitySemantic proximity
Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functionsSemantic proximity
Longitudinal dynamic single-cell mass cytometry analysis of peripheral blood mononuclear cells in COVID-19 patients within 6 months after viral RNA clearanceSemantic proximity
Select a neighboring publication to make it the new centre.