Article
Classifying the evolutionary and ecological features of neoplasms.
Nature reviews. Cancer - 1 Oct 2017
Maley Carlo C, Aktipis Athena, Graham Trevor A, Sottoriva Andrea, Boddy Amy M, Janiszewska Michalina, Silva Ariosto S, Gerlinger Marco, Yuan Yinyin, Pienta Kenneth J, Anderson Karen S, Gatenby Robert, Swanton Charles, Posada David, Wu Chung-I, Schiffman Joshua D, Hwang E Shelley, Polyak Kornelia, Anderson Alexander R A, Brown Joel S, Greaves Mel, Shibata Darryl
Abstract excerpt
Neoplasms change over time through a process of cell-level evolution, driven by genetic and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic cell determines which changes provide adaptive benefits. There is widespread recognition of the importance of these evolutionary and ecological processes in cancer, but to date, no system has been proposed for drawing clinically relevant...
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