Article

Evolutionary dynamics and molecular features of intra-tumor heterogeneity

2017-11-06

Abstract excerpt

The systematic assessment of intra-tumor heterogeneity is still limited and often unfeasible. In silico investigations of large tumor cohorts can be used to decipher how multiple clones emerge and organize into complex architectures. Here, we addressed this challenge by integrating mathematical modeling of cancer evolution with algorithmic inference of clonal phylogenies in 2,600 human tumors from 15 tumor types....

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Identifiers and source

Literature Corpus work: ae8c63e7-9ffc-5468-a10e-404937c3ea69
DOI: 10.1101/214791

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