Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity.

Nature - 10 Sept 2015

Waclaw Bartlomiej, Bozic Ivana, Pittman Meredith E, Hruban Ralph H, Vogelstein Bert, Nowak Martin A

Abstract excerpt

Most cancers in humans are large, measuring centimetres in diameter, and composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is that virtually every neoplastic cell within a large tumour often contains the same core set of genetic alterations, with heterogeneity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Movement
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Models, Biological

Share to Neoplasms

Share to Selection, Genetic

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26308893
DOI: 10.1038/nature14971
PMCID: PMC4782800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity.PMID 26308893Read ↗

Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneitySemantic proximity Read ↗

Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.Semantic proximity Read ↗

Spatial structure governs the mode of tumour evolutionSemantic proximity Read ↗

Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation.Semantic proximity Read ↗

First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer.Semantic proximity Read ↗

Evolutionary scalpels for dissecting tumor ecosystems.Semantic proximity Read ↗

Tissue structure accelerates evolution: premalignant sweeps precede neutral expansionSemantic proximity Read ↗

First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancerSemantic proximity Read ↗

Clone Phylogenetics Reveals Metastatic Tumor Migrations, Maps, and ModelsSemantic proximity Read ↗

Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.Semantic proximity Read ↗

Emergent Stratification in Solid Tumors Selects for Reduced Cohesion of Tumor Cells: A Multi-Cell, Virtual-Tissue Model of Tumor Evolution Using CompuCell3D.Semantic proximity Read ↗

A mathematical framework for modelling the metastatic spread of cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.