Article

Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity

2015-03-20

Abstract excerpt

Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is their homogeneity - virtually every neoplastic cell within a large cancer contains the same core set of genetic alterations, with heterogeneity...

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Identifiers and source

Literature Corpus work: 96c70e34-90a4-5293-aceb-3892dcc31f4a
DOI: 10.1101/016824

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