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Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine

1 Jan 2016

Abstract excerpt

The ability to predict the future behavior of an individual cancer is crucial for precision cancer medicine. The discovery of extensive intratumor heterogeneity and ongoing clonal adaptation in human tumors substantiated the notion of cancer as an evolutionary process. Random events are inherent in evolution and tumor spatial structures hinder the efficacy of selection, which is the only deterministic...

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PMID: 26949746
DOI: 10.1016/j.trecan.2015.11.003

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