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Article

Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.

Open biology - 1 Apr 2020

Jiang Xiaowei, Tomlinson Ian P M

Abstract excerpt

One of the great unsolved puzzles in cancer biology is not why cancers occur, but rather explaining why so few cancers occur compared with the theoretical number that could occur, given the number of progenitor cells in the body and the normal mutation rate. We hypothesized that a contributory explanation is that the tumour microenvironment (TME) is not fixed due to factors such as immune cell infiltration, and...

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Identifiers

PMID: 32289242
DOI: 10.1098/rsob.190297
PMCID: PMC7241076

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