Article
Spatial mutation patterns as markers of early colorectal tumor cell mobility.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2018
Ryser Marc D, Min Byung-Hoon, Siegmund Kimberly D, Shibata Darryl
Abstract excerpt
A growing body of evidence suggests that a subset of human cancers grows as single clonal expansions. In such a nearly neutral evolution scenario, it is possible to infer the early ancestral tree of a full-grown tumor. We hypothesized that early tree reconstruction can provide insights into the mobility phenotypes of tumor cells during their first few cell divisions. We explored this hypothesis by means of a...
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