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Article

Between-region genetic divergence reflects the mode and tempo of tumor evolution.

Nature genetics - 1 Jul 2017

Sun Ruping, Hu Zheng, Sottoriva Andrea, Graham Trevor A, Harpak Arbel, Ma Zhicheng, Fischer Jared M, Shibata Darryl, Curtis Christina

Abstract excerpt

Given the implications of tumor dynamics for precision medicine, there is a need to systematically characterize the mode of evolution across diverse solid tumor types. In particular, methods to infer the role of natural selection within established human tumors are lacking. By simulating spatial...

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Identifiers

PMID: 28581503
DOI: 10.1038/ng.3891
PMCID: PMC5643198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28581503-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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