Article

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

2023-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Ribosomes are the supramolecular complexes responsible for protein synthesis. The large 50S ribosomal subunit catalyzes the peptidyl transferase reaction and peptide bond formation between amino acids. The 50S is targeted by many known clinically effective antibiotics. Available structures, obtained at cryogenic temperatures (CT), are used for drug discovery despite that active or important targ...

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Literature Corpus work: 5b734ab0-e3e8-5c49-a60b-3e35ccf34b8b
DOI: 10.1101/2023.10.24.563633

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