Article

Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

2023-06-13

Abstract excerpt

<h4>SUMMARY</h4> Around 50% of the current antibiotic arsenal targets the ribosome, thus resistance to ribosome-targeting antibiotics poses severe challenges to antimicrobial treatments. Here, we characterize a 12-nucleotide deletion in the rplF gene encoding the uL6 ribosomal protein, which was identified in a tobramycin-resistant strain of Pseudomonas aeruginosa isolated from a cystic fibrosis patient. To und...

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Literature Corpus work: 76a5955a-dac8-58b9-9419-5de6d079bc91
DOI: 10.1101/2023.06.13.544509

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