Article

Fidaxomicin jams <i>M. tuberculosis</i> RNA polymerase motions needed for initiation via RbpA contacts

2018-01-08

Abstract excerpt

Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro , but clinical use of Fdx is limited to treating Clostridium difficile intestinal infections due to poor absorption. To enable structure-guided optimization of Fdx to treat tuberculosis, we report the 3.4 Å cryo-electron microscopy structure of a complete M. tuberculosis RNAP...

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Literature Corpus work: eff18e01-01b8-5dad-b215-57b3dde50dd9
DOI: 10.1101/244533

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