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Article

Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

9 May 2016

Abstract excerpt

Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs. Using electron cryo-microscopy of a single specimen, we present five ribosome structures formed with the Taura syndrome virus IRES and translocase eEF2•GTP bound with sordarin. The structures suggest a trajectory of IRES translocation, required for translation initiation, and provide an unprecedented view of eEF2 dynamics....

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PMID: 27159452
DOI: 10.7554/elife.14874

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