Article
Puf6 primes 60S pre-ribosome nuclear export at low temperature.
Nature communications - 4 Aug 2021
Gerhardy Stefan, Oborská-Oplová Michaela, Gillet Ludovic, Börner Richard, van Nues Rob, Leitner Alexander, Michel Erich, Petkowski Janusz J, Granneman Sander, Sigel Roland K O, Aebersold Ruedi, Panse Vikram Govind
Abstract excerpt
Productive ribosomal RNA (rRNA) compaction during ribosome assembly necessitates establishing correct tertiary contacts between distant secondary structure elements. Here, we quantify the response of the yeast proteome to low temperature (LT), a condition where aberrant mis-paired RNA folding intermediates accumulate. We show that, at LT, yeast cells globally boost production of their ribosome assembly machinery....
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