Article

Structures of the <i>Staphylococcus aureus</i> ribosome inhibited by fusidic acid and fusidic acid cyclopentane

2023-11-20

Abstract excerpt

<h4>ABSTRACT</h4> The antibiotic fusidic acid (FA) is used to treat Staphylococcus aureus infections. It inhibits protein synthesis by binding to elongation factor G (EF-G) and preventing its release from the ribosome after translocation. While FA is only effective against gram-positive bacteria, the available structures of FA-inhibited complexes are from gram-negative model organisms. To fill this knowledge gap...

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Literature Corpus work: e46d2b7c-45bf-53cd-afda-49774d9dab57
DOI: 10.1101/2023.11.17.567578

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