Article

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

2024-08-07

Abstract excerpt

Protein Tyrosine Phosphatase 1B (PTP1B) is a negative regulator of leptin signaling whose disruption protects against diet-induced obesity in mice. We investigated whether structural characterization of human PTP1B variant proteins might reveal allosteric sites to target for weight loss therapy. To do so, we selected 12 rare variants for functional characterization from exomes from 997 people with persistent thinn...

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Literature Corpus work: c24c079f-562f-5d86-a2d9-d9b3968413c8
DOI: 10.1101/2024.08.05.603709

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