Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases

23 Jun 2020

Abstract excerpt

Significance Sphingolipids (SLs) are complex lipids that constitute hundreds of subspecies. All SLs share a long-chain base (LCB) as a defining structural component. LCBs are formed by serine-palmitoyltransferase (SPT) in the first and rate-limiting step of SL de novo synthesis. SPT consists of three subunits that show tissue-specific expression. In presence of the SPTLC3 subunit, the enzyme forms a spectrum of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, Metabolism, and Disease
Share to Lipid metabolism and biosynthesis
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32576697
DOI: 10.1073/pnas.2002391117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain basesPMID 32576697Read ↗

The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.Semantic proximity Read ↗

Structural insights into the regulation of human serine palmitoyltransferase complexes.Semantic proximity Read ↗

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiologySemantic proximity Read ↗

Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.Semantic proximity Read ↗

1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma.Semantic proximity Read ↗

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.Semantic proximity Read ↗

Sphingolipids and Asthma.Semantic proximity Read ↗

Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.Semantic proximity Read ↗

Sphingolipid remodelling in SPT-related neuropathiesSemantic proximity Read ↗

Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLDSemantic proximity Read ↗

SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegiaSemantic proximity Read ↗

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain basesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.