Article

Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease

2021-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Olduvai protein domains (formerly DUF1220) show the greatest human-specific increase in copy number of any coding region in the genome and are highly correlated with human brain evolution and cognitive disease. The majority of human copies are found within four NBPF genes organized in a variable number of a tandemly arranged three-domain blocks called Olduvai triplets. Here we show that these h...

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Literature Corpus work: 5b2bfa15-702a-5d2f-b869-30a0bb889ff1
DOI: 10.1101/2021.07.06.450945

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