Article

Upstream open reading frames may contain hundreds of novel human exons

2024-03-23

Abstract excerpt

Several recent studies have presented evidence that the human gene catalogue should be expanded to include thousands of short open reading frames (ORFs) appearing upstream or downstream of existing protein-coding genes, each of which would comprise an additional bicistronic transcript in humans. Here we explore an alternative hypothesis that would explain the translational and evolutionary evidence for these upstr...

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Literature Corpus work: 3c4f9cb9-dd31-5007-a74f-2698ce2ba414
DOI: 10.1101/2024.03.22.586333

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