Article
Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006
Zhang Xiang H-F, Chasin Lawrence A
Abstract excerpt
Orthologous gene structures in eight vertebrate species were compared on a genomic scale to detect the birth and maturation of new internal exons during the course of evolution. We found that 40% of new human exons are alternatively spliced, and most of these are cassette exons (exons that are either included or skipped in their entirety) with low inclusion rates. This proportion decreases steadily as older and...
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