Article

Evolutionary hotspots of structural variation drive inter-individual differences in the expression of fusion transcripts in the human brain

2025-03-12

Abstract excerpt

While most protein-coding regions in our genome are highly conserved, phenotypic variation largely arises from differences in gene transcription, splicing, and translation. Intra-gene splicing variations are a known source of inter-individual differences. However, inter-gene splicing events, which generate fusion transcripts—RNA molecules combining exons from multiple distinct genes—are less explored. Fusion trans...

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Literature Corpus work: 3eefa5ff-9090-58e4-884b-91bf11b1a70c
DOI: 10.1101/2025.03.11.642572

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