Article
De novo origin of human protein-coding genes.
PLoS genetics - 1 Nov 2011
Wu Dong-Dong, Irwin David M, Zhang Ya-Ping
Abstract excerpt
The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA-seq data indicate that these genes have their highest expression...
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