Article

Olduvai Domains Downregulate Mitochondrial Pathways to Promote Human Brain Evolution and Neoteny

2026-07-18

Abstract excerpt

<title>Abstract</title> <p>Olduvai (formerly DUF1220) protein domains, encoded by the NBPF gene family, have undergone the greatest human lineage-specific copy-number expansion of any coding sequence in the genome and strongly correlate with brain size and neuron number across primates. Here we show that Olduvai domains act in a dosage-dependent manner to suppress mitochondrial metabolism. Transcriptomic, proteom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 688a34f3-51a0-5835-ae49-3e2fb1dc336a
DOI: 10.21203/rs.3.rs-10345985/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Olduvai Domains Downregulate Mitochondrial Pathways to Promote Human Brain Evolution and NeotenyDOI 10.21203/rs.3.rs-10345985/v1Read

Olduvai Domains Downregulate Mitochondrial Pathways to Promote Human Brain Evolution and NeotenySemantic proximity Read

Proteolytic Activation of Human-specific Olduvai Domains by the Furin ProteaseSemantic proximity Read

A catalog of single nucleotide changes distinguishing modern humans from archaic homininsSemantic proximity Read

DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primatesSemantic proximity Read

Palindrome-mediated 16p13.3 triplications cause a recognizable neurodegenerative disorder with ataxia.Semantic proximity Read

Unfolding neural diversity: how dynamic three-dimensional genome architecture regulates brain function and disease.Semantic proximity Read

Changing the name of the NBPF/DUF1220 domain to the Olduvai domainSemantic proximity Read

MTALTND4, a second protein coded by <i>nd4</i> impacts mitochondrial bioenergeticsSemantic proximity Read

Multimodal brain cell atlas across the adult macaque lifespanSemantic proximity Read

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and VulnerabilitySemantic proximity Read

Oxidative-phosphorylation genes from the mitochondrial and nuclear genomes co-express in all human tissues except for the ancient brainSemantic proximity Read

A Human Brain Map of Mitochondrial Respiratory Capacity and DiversitySemantic proximity Read