Article

De novo birth of functional, human-specific microproteins

2021-10-02

Abstract excerpt

We now have a growing understanding that functional short proteins can be translated out of small Open Reading Frames (sORF). Such “microproteins” can perform crucial biological tasks and can have considerable phenotypic consequences. However, their size makes them less amenable to genomic analysis, and their evolutionary origins and conservation are poorly understood. Given their short length it is plausible that...

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Literature Corpus work: 3ec601df-8a29-58e4-8c1f-133743a7f2a8
DOI: 10.1101/2021.10.01.462744

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