Article

Olduvai Domains Downregulate Mitochondrial Pathways to Promote Human Brain Evolution and Neoteny

2024-10-22

Abstract excerpt

Olduvai (formerly DUF1220) protein domains, encoded by the NBPF gene family, have undergone the greatest human lineage-specific copy-number expansion of any coding sequence in the genome and strongly correlate with brain size and neuron number across primates. Here we show that Olduvai domains act in a dosage-dependent manner to suppress mitochondrial metabolism. Transcriptomic, proteomic, and live-cell imaging an...

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Literature Corpus work: c95f7902-f504-5af3-a49e-c461dff43114
DOI: 10.1101/2024.10.21.619278

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