Article

Spatiotemporal Patterns of Active Deformation Reveal Downregulation of Cell-Cell Adhesion in Patient-Derived Colorectal Cancer Organoids with <i>BRAF</i> Mutations

2026-03-08

Abstract excerpt

Colorectal cancer (CRC) is the second most common cause of cancer-related mortality. At the molecular level, CRC is associated with genetic mutations and epigenetic modifications that dysregulate various signaling networks. From the biophysical viewpoint, invasive and metastatic cell migration need to be empowered by mechanical forces. In this study, we analyze the dynamic deformation of patient-derived CRC organo...

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Literature Corpus work: 5b214393-0821-5329-b093-bcb930785618
DOI: 10.64898/2026.03.07.710277

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Spatiotemporal Patterns of Active Deformation Reveal Downregulation of Cell-Cell Adhesion in Patient-Derived Colorectal Cancer Organoids with <i>BRAF</i> MutationsDOI 10.64898/2026.03.07.710277Read

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