Article

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

2023-12-03

Abstract excerpt

The intricate interplay between actomyosin contractility and extracellular matrix (ECM) strain stiffening is pivotal in cancer invasion. Despite the admitted impact of such feedback, current models are inadequate in predicting the largely overlapping ranges of cell shapes and their corresponding motility levels at intermediate ranges of collagen density. To address this gap, we introduce a free energy-based, trizo...

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Literature Corpus work: 96354e2a-04a4-5024-8bb9-1899026e4ccb
DOI: 10.1101/2023.12.02.569730

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