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Article

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.

Nature communications - 18 Apr 2024

Conti Sefora, Venturini Valeria, Cañellas-Socias Adrià, Cortina Carme, Abenza Juan F, Stephan-Otto Attolini Camille, Middendorp Guerra Emily, Xu Catherine K, Li Jia Hui, Rossetti Leone, Stassi Giorgio, Roca-Cusachs Pere, Diz-Muñoz Alba, Ruprecht Verena, Guck Jochen, Batlle Eduard, Labernadie Anna, Trepat Xavier

Abstract excerpt

Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is poorly understood. Using CRC patient derived organoids (PDOs), we find that compared to LGR5- cells, LGR5+ cancer stem cells are...

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Identifiers

PMID: 38637494
DOI: 10.1038/s41467-024-47227-2
PMCID: PMC11026456

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