Article

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

2023-12-05

Abstract excerpt

Colorectal cancer tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is unknown. Using CRC patient derived organoids (PDOs), we found that compared to LGR5- cells, LGR5+ cancer stem cells are stiffer, adhere...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f46a8d3-3265-52cc-a6df-38a3d8b6d17c
DOI: 10.1101/2023.12.04.569244

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cellsDOI 10.1101/2023.12.04.569244Read

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.Semantic proximity Read

Single-cell spatial multiomics identifies <i>POSTN</i> <sup>+</sup> CAFs mediating chemoradiotherapy resistance in rectal cancerSemantic proximity Read

Single-cell and Spatial Transcriptomic Mapping Reveals MSEC-myoCAF Interactions Driving Lymph Node Metastasis in Colorectal CancerSemantic proximity Read

CD44+ cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edgeSemantic proximity Read

Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancerSemantic proximity Read

Spatiotemporal Patterns of Active Deformation Reveal Downregulation of Cell-Cell Adhesion in Patient-Derived Colorectal Cancer Organoids with <i>BRAF</i> MutationsSemantic proximity Read

Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancerSemantic proximity Read

DLC1 loss drives multicellular streaming invasion by enforcing spatially coordinated Rho and β1 integrin signalingSemantic proximity Read

The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachmentSemantic proximity Read

Cancer cell mechanobiology: a new frontier for cancer researchSemantic proximity Read

Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression.Semantic proximity Read

RHAMM marks proliferative subpopulation of human colorectal cancer stem cellsSemantic proximity Read