Article

Mechanical confinement governs phenotypic plasticity in melanoma

2024-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes - proliferative versus invasive states. While it has long been hypothesised that such switching is triggered by external cues, the identity of these cues has remained elusive. Here, we demonstrate that mechanical confinement mediates phenotype switching through chromatin remod...

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Literature Corpus work: 60c71529-b535-5a50-8424-e949a30b308d
DOI: 10.1101/2024.01.30.577120

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