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Article

Changes in cellular mechanical properties during onset or progression of colorectal cancer.

World journal of gastroenterology - 28 Aug 2016

Ciasca Gabriele, Papi Massimiliano, Minelli Eleonora, Palmieri Valentina, De Spirito Marco

Abstract excerpt

Colorectal cancer (CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes. These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A...

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Identifiers

PMID: 27621568
DOI: 10.3748/wjg.v22.i32.7203
PMCID: PMC4997642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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