Article
Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jan 2026
Huning Nicole C, Buhaya Munir H, Nguyen Victor V, Khazi-Syed Afeefah, Ali Haider A, Khan Adil, Fan Angela, Fisher Robert C, Chi Zhikai, Raman Indu, Chen Guangchun, Zhu Chengsong, Yu Mengxi, Jamieson Andrew R, Roccabianca Sara, Varner Victor D, Lewis Cheryl M, Huang Emina H, Ferruzzi Jacopo
Abstract excerpt
While both incidence and mortality of sporadic average-onset colorectal cancer (AO CRC, above 50 years of age) are in constant decline, sporadic early-onset colorectal cancer (EO CRC, under 50 years of age) is rising rapidly. Yet, the causes behind this rise remain poorly understood. Epidemiological studies indicate that lifestyle and environmental exposures may result in chronic inflammation, which is known to...
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