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Article

IDH1 R132H and TP53 R248Q Mutations Modulate Glioma Cell Migration and Adhesion on Different ECM Components.

International journal of molecular sciences - 13 Nov 2024

Shmelev Mikhail E, Pilnik Andrei A, Shved Nikita A, Penkova Alina O, Gulaia Valeriia S, Kumeiko Vadim V

Abstract excerpt

Mutations in IDH1 and TP53 have a significant impact on glioma prognosis and progression; however, their roles in tumor cell invasion in terms of interactions with particular components of the extracellular matrix (ECM) are still unclear. Using gene editing protocol based on CRISPR-Cas 9 with cytidine deaminase, we introduced point mutations into U87MG glioblastoma cells to establish modified cell lines with...

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Identifiers

PMID: 39596246
DOI: 10.3390/ijms252212178
PMCID: PMC11594609

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