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Article

Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells.

Scientific reports - 24 Feb 2020

Armistead Fern J, Gala De Pablo Julia, Gadêlha Hermes, Peyman Sally A, Evans Stephen D

Abstract excerpt

Disease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic and their response to an applied stress is highly dependent on the magnitude and timescale of the actuation. Microfluidics can be used to measure cell...

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PMID: 32094413
DOI: 10.1038/s41598-020-59952-x
PMCID: PMC7039955

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