Article

Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in Schizophrenia

2024-01-01

Abstract excerpt

<title>Abstract</title> <p>The expression of Neuritin-1 (<italic>NRN1</italic>), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (<italic>BDNF</italic>). Although the receptor of NRN1 remains unclear, it is suggested that NRN1's activation of the insulin receptor (IR) pathway promotes the transcription of the calcium voltage-gated ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5aba2a99-b72e-5c55-b19d-498f1d874b4c
DOI: 10.21203/rs.3.rs-3812871/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in SchizophreniaDOI 10.21203/rs.3.rs-3812871/v1Read

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.Semantic proximity Read

Epistasis in the risk of human neuropsychiatric disease.Semantic proximity Read

Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning.Semantic proximity Read

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function.Semantic proximity Read

Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study.Semantic proximity Read

Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders.Semantic proximity Read

Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders.Semantic proximity Read

The interaction of RELN-DNMT genes involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility.Semantic proximity Read

Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Semantic proximity Read

Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.Semantic proximity Read

Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.Semantic proximity Read

Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disordersSemantic proximity Read