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Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders

2 Jun 2021

Abstract excerpt

Abstract Background Observational studies have identified various associations between neuroimaging alterations and neuropsychiatric disorders. However, whether such associations could truly reflect causal relations remains still unknown. Results Here, we leveraged genome-wide association studies (GWAS) summary statistics for (1) 11 psychiatric disorders (sample sizes varied from n = 9,725 to 1,331,010); (2) 110...

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PMID: 34078268
DOI: 10.1186/s12864-021-07661-8

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