Article
The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function.
Genes, brain, and behavior - 1 Apr 2019
Tecelão Diogo, Mendes Ana, Martins Daniel, Fu Cynthia, Chaddock Christopher A, Picchioni Marco M, McDonald Colm, Kalidindi Sridevi, Murray Robin, Prata Diana P
Abstract excerpt
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes. As these patients show abnormal verbal fluency (VF) and related brain activation, we asked whether the latter was affected by these polymorphisms (alone and in interaction)-to better understand how they might induce risk. We recently...
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