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Article

Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.

Translational psychiatry - 2 Oct 2024

Federmann Lydia M, David Friederike S, Jockwitz Christiane, Mühleisen Thomas W, Pelzer Dominique I, Nöthen Markus M, Caspers Svenja, Amunts Katrin, Goltermann Janik, Andlauer Till F M, Stein Frederike, Brosch Katharina, Kircher Tilo, Cichon Sven, Dannlowski Udo, Sindermann Lisa, Forstner Andreas J

Abstract excerpt

A previously published genome-wide association study (GWAS) meta-analysis across eight neuropsychiatric disorders identified antagonistic single-nucleotide polymorphisms (SNPs) at eleven genomic loci where the same allele was protective against one neuropsychiatric disorder and increased the risk for another. Until now, these antagonistic SNPs have not been further investigated regarding their link to brain...

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PMID: 39358328
DOI: 10.1038/s41398-024-03098-1
PMCID: PMC11446931

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