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Article

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.

Brain structure & function - 1 Jun 2024

Almodóvar-Payá Carmen, Guardiola-Ripoll Maria, Giralt-López Maria, Oscoz-Irurozqui Maitane, Canales-Rodríguez Erick Jorge, Madre Mercè, Soler-Vidal Joan, Ramiro Núria, Callado Luis F, Arias Bárbara, Gallego Carme, Pomarol-Clotet Edith, Fatjó-Vilas Mar

Abstract excerpt

The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF). Although the receptor of NRN1 remains unclear, it is suggested that NRN1's activation of the insulin receptor (IR) pathway promotes the transcription of the calcium voltage-gated channel subunit alpha1 C (CACNA1C). These three genes have been...

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Identifiers

PMID: 38720004
DOI: 10.1007/s00429-024-02793-5
PMCID: PMC11147852

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