Article
Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.
Archives of general psychiatry - 1 Oct 2010
Nicodemus Kristin K, Law Amanda J, Radulescu Eugenia, Luna Augustin, Kolachana Bhaskar, Vakkalanka Radhakrishna, Rujescu Dan, Giegling Ina, Straub Richard E, McGee Kate, Gold Bert, Dean Michael, Muglia Pierandrea, Callicott Joseph H, Tan Hao-Yang, Weinberger Daniel R
Abstract excerpt
CONTEXT: NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. OBJECTIVE: To examine epistasis between NRG1 and selected N-methyl-d-aspartate-glutamate pathway partners implicated in its effects, including ERBB4, AKT1, DLG4, NOS1, and NOS1AP. DESIGN: Schizophrenia case-control sample...
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